\u3000\u3053\u3093\u306b\u3061\u306f\u3001\u6771\u671b\u5927\u4e45\u4fdd\u533b\u9662\u306e\u5927\u4e45\u4fdd\u4ec1\u3067\u3059\u3002\u3064\u3044\u306b\u6885\u96e8\u5165\u308a\u3068\u306a\u308a\u307e\u3057\u305f\u3002<\/p>\n
\u3000\u30a4\u30ce\u30f4\u30a7\u30fc\u30b7\u30e7\u30f3(Innovation)\u3001\u305d\u306e\u307e\u307e\u8a33\u3059\u3068\u9769\u65b0\u3002\u30d6\u30ec\u30a4\u30af\u30b9\u30eb\u30fc(Breakthrough)\u3001\u884c\u304d\u8a70\u307e\u308a\u72b6\u614b\u306e\u6253\u958b\u3001\u79d1\u5b66\u6280\u8853\u304c\u98db\u8e8d\u7684\u306b\u9032\u6b69\u3059\u308b\u3053\u3068\u3002\u7d4c\u55b6\u8005\u3068\u304b\u3001\u73fe\u6771\u4eac\u90fd\u77e5\u4e8b\u306a\u3069\u304c\u597d\u304d\u305d\u3046\u306a\u8a00\u8449\u3060\u308d\u3046\u306a\u3068\u601d\u3044\u307e\u3059\u3002<\/p>\n
\u00a0\u3000American Society of Clinical Oncology (ASCO) \u304c\u4eca\u5e74\u3082\u30b7\u30ab\u30b4\u3067\u958b\u50ac\u3055\u308c\u307e\u3057\u305f\u3002ASCO\u306f\u304c\u3093\u3084\u816b\u760d\u5b66\u306b\u3064\u3044\u3066\u306e\u3082\u3063\u3068\u3082\u5927\u304d\u306a\u5b66\u4f1a\u306e\u4e00\u3064\u3067\u3001\u6bce\u5e74\u3001\u30a2\u30e1\u30ea\u30ab\u306e\u30b7\u30ab\u30b4\u3067\u3053\u306e\u6642\u671f\u306b\u958b\u50ac\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u4e73\u304c\u3093\u306e\u5206\u91ce\u3067\u306f\u7d30\u80de\u5468\u671f\u963b\u5bb3\u85ac\u306e\u4e00\u3064\u3067\u3001\u30b5\u30a4\u30af\u30ea\u30f3\u4f9d\u5b58\u6027\u30ad\u30ca\u30fc\u30bc4\/6\u963b\u5bb3\u85ac\u3068\u3044\u3046\u3001\u9577\u3044\u96e3\u3057\u305d\u3046\u306a\u540d\u524d\u3067\u3059\u304c\u3001\u30aa\u30d7\u30b8\u30fc\u30dc\u306a\u3069\u306e\u514d\u75ab\u30c1\u30a7\u30c3\u30af\u30dd\u30a4\u30f3\u30c8\u963b\u5bb3\u85ac\u3068\u540c\u69d8\u306b\u6700\u8fd1\u3001\u975e\u5e38\u306b\u671f\u5f85\u3055\u308c\u3066\u3044\u308b\u85ac\u3067\u3001\u305d\u306e\u4e2d\u306e\u30a2\u30d9\u30de\u30b7\u30af\u30ea\u30d6\u3068\u4e73\u304c\u3093\u306e\u30db\u30eb\u30e2\u30f3\u6cbb\u7642\u85ac\u3067\u3042\u308b\u30d5\u30eb\u30d9\u30b9\u30c8\u30e9\u30f3\u30c8\uff08\u6ce8\u5c04\u85ac\uff09\u3068\u306e\u4f75\u7528\u7642\u6cd5\u306e\u81e8\u5e8a\u8a66\u9a13\u3001MONARCH-2\u8a66\u9a13\uff08\u4e73\u304c\u3093\u3092\u5c02\u9580\u3068\u3057\u3066\u3044\u308b\u533b\u5e2b\u304b\u3089\u306f\u975e\u5e38\u306b\u6ce8\u76ee\u3055\u308c\u3066\u3044\u305f\u8a66\u9a13\u3068\u601d\u3044\u307e\u3059\uff09\u306e\u7d50\u679c\u304c\u5831\u544a\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n
\u3000MONARCH-2\u8a66\u9a13\u306e\u5185\u5bb9\u306f\u3053\u306e\u3088\u3046\u306a\u3082\u306e\u3067\u3059\u3002\u30db\u30eb\u30e2\u30f3\u967d\u6027\/HER2\u9670\u6027\u9032\u884c\u4e73\u304c\u3093\u3067\u305d\u308c\u307e\u3067\u306b\u5185\u5206\u6ccc\u7642\u6cd5\u3092\u53d7\u3051\u3066\u3001\u305d\u306e\u5f8c\u9032\u884c\u3057\u305f\u60a3\u8005\u3055\u3093\u304c\u5bfe\u8c61\u306e\u8a66\u9a13\u3067\u3059\u3002\u5168\u90e8\u3067669\u540d\u304c\u3053\u306e\u8a66\u9a13\u306b\u53c2\u52a0\u3055\u308c\u305f\u305d\u3046\u3067\u3059\u3002\u53c2\u52a0\u8005\u306f\u30a2\u30d9\u30de\u30b7\u30af\u30ea\u30d6\uff0b\u30d5\u30eb\u30d9\u30b9\u30c8\u30e9\u30f3\u30c8\u306e\u7642\u6cd5\u306e\u6cbb\u7642\u3092\u53d7\u3051\u305f\u7fa4(A+F\u7fa4\uff09\u3068\u30d7\u30e9\u30bb\u30dc\uff08\u507d\u85ac\uff09\uff0b\u30d5\u30eb\u30d9\u30b9\u30c8\u30e9\u30f3\u30c8\u7fa4(P+F\u7fa4\uff09\u306b2\uff1a1\u306b\u7121\u4f5c\u70ba\u306b\u5272\u308a\u5f53\u3066\u3089\u308c\u307e\u3057\u305f\u3002<\/p>\n
\u3000\u4e3b\u8981\u8a55\u4fa1\u9805\u76ee\uff08\u4e00\u756a\u76ee\u306b\u8a55\u4fa1\u3059\u308b\u9805\u76ee\uff09\u306f\u3001\u75c5\u6c17\u304c\u60aa\u304f\u306a\u3089\u306a\u3044\u3067\u751f\u5b58\u3057\u3066\u3044\u308b\u671f\u9593\uff08\u7121\u5897\u60aa\u751f\u5b58\u671f\u9593\uff1aPFS)\u3001\u526f\u6b21\u7684\u8a55\u4fa1\u9805\u76ee\uff08\u305d\u306e\u4ed6\u306e\u9805\u76ee\uff09\u3068\u3057\u3066\u3001\u5ba2\u89b3\u7684\u594f\u52b9\u7387\uff08\u3069\u306e\u304f\u3089\u3044\u85ac\u304c\u52b9\u3044\u305f\u304b\uff09\u3001\u5b89\u5168\u6027\u306f\u3069\u3046\u3060\u3063\u305f\u304b\u3001\u526f\u4f5c\u7528\u306f\u3069\u3046\u3060\u3063\u305f\u304b\u3067\u3057\u305f\u3002<\/p>\n
\u3000\u7d50\u679c\uff1a19.5\u30f6\u6708\u9593\u306e\u89b3\u5bdf\u671f\u9593\uff08\u4e2d\u592e\u5024\uff09\u3067\u3001PFS\u306f\u3001A+F\u7fa4\uff1a16.4\u30f6\u6708\u3001P+F\u7fa4\uff1a9.3\u30f6\u6708\u3067\u3001A+F\u7fa4\u306e\u65b9\u304c44.7%\u5206\u3001\u75c5\u6c17\u304c\u60aa\u304f\u306a\u3089\u306a\u3044\u3067\u751f\u5b58\u3057\u3066\u3044\u308b\u671f\u9593\u304c\u9577\u304f\u306a\u3063\u305f\u3068\u3044\u3046\u3053\u3068\u3067\u3059\u3002\u3082\u3068\u3082\u3068\u3053\u306e\u65b0\u3057\u3044\u6cbb\u7642\u6cd5\u306730%\u304f\u3089\u3044\u826f\u304f\u306a\u308b\u3068\u4eee\u5b9a\u3057\u3066\u3044\u305f\u3068\u306e\u3053\u3068\u3001\u304b\u306a\u308a\u306e\u6539\u5584\u5ea6\u3067\u306f\u306a\u3044\u3067\u3057\u3087\u3046\u304b\uff1f\u594f\u52b9\u7387\u306f\u3001A+F\u7fa4\uff1a48.1%\u3001P+F\u7fa4\uff1a21.3%\u3002\u526f\u4f5c\u7528\u306f\u3001A+F\u7fa4\u3067\u591a\u304f\u898b\u3089\u308c\u305f\u526f\u4f5c\u7528\u306f\u3001\u4e0b\u75e2\u3001\u597d\u4e2d\u7403\u6e1b\u5c11\u3001\u60aa\u5fc3\u3001\u75b2\u52b4\u611f\u3068\u306e\u3053\u3068\u3067\u3057\u305f\u3002<\/p>\n
\u3000\u5c11\u3057\u524d\u306b\u8a71\u984c\u306b\u306a\u3063\u305f\u65b0\u85ac\u3068\u3057\u3066\u3001\u60aa\u6027\u9ed2\u8272\u816b\u3084\u975e\u5c0f\u7d30\u80de\u6027\u80ba\u304c\u3093\u306b\u5bfe\u3059\u308b\u514d\u75ab\u30c1\u30a7\u30c3\u30af\u30dd\u30a4\u30f3\u30c8\u963b\u5bb3\u85ac\u306e\u30aa\u30d7\u30b8\u30fc\u30dc\u304c\u3042\u308a\u307e\u3059\u3002\u304c\u3093\u6cbb\u7642\u306e\u30a4\u30ce\u30f4\u30a7\u30fc\u30b7\u30e7\u30f3\u3084\u203c\ufe0e\u3068\u8a00\u308f\u308c\u3001\u5024\u6bb5\u304c\u3081\u3061\u3083\u304f\u3061\u3083\u9ad8\u304b\u3063\u305f\u308a\u3001\u308f\u3051\u308f\u304b\u3089\u3093\u307e\u307e\u5024\u6bb5\u304c\u534a\u5206\u306b\u306a\u3063\u305f\u308a\u3001\u9031\u520a\u8a8c\u306a\u3069\u3067\u300c\u80ba\u304c\u3093\u304c\u6d88\u3048\u305f\u3001\u9b54\u6cd5\u306e\u85ac\u300d\u306a\u3069\u306e\u8a18\u8f09\u304c\u3042\u3063\u305f\u308a\u3001\u3068\u3053\u306e\u624b\u306e\u85ac\u306f\u8a71\u984c\u306b\u4e8b\u6b20\u304d\u307e\u305b\u3093\u3002\u514d\u75ab\u30c1\u30a7\u30c3\u30af\u30dd\u30a4\u30f3\u30c8\u963b\u5bb3\u85ac\u306f\u3059\u3067\u306b\u30aa\u30d7\u30b8\u30fc\u30dc\u306e\u4ed6\u3001\u30ad\u30a4\u30c8\u30eb\u30fc\u30c0\u3001\u30e4\u30fc\u30dc\u30a4\u306a\u3069\u8907\u6570\u306e\u85ac\u304c\u51fa\u3066\u3044\u307e\u3059\u3057\uff08\u30aa\u30d7\u30b8\u30fc\u30dc\u306f\u8ee2\u79fb\u30fb\u518d\u767a\u80c3\u304c\u3093\u306b\u3082\u7533\u8acb\u3057\u3066\u3044\u308b\u3088\u3046\u3067\u3059\uff09\u3001\u4eca\u5f8c\u3082\u3069\u3093\u3069\u3093\u51fa\u3066\u304d\u307e\u3059\u3002<\/p>\n
\u3000\u3053\u306e\u3088\u3046\u306a\u65b0\u85ac\u306e\u60c5\u5831\u306e\u6e26\u306e\u4e2d\u3067\u3001\u60a3\u8005\u3055\u3093\u306f\u300c\u4f55\u3092\u4fe1\u3058\u308c\u3070\u3044\u3044\u306e\u304b\u308f\u304b\u3089\u3093\u300d\u3001\u3068\u3044\u3046\u304a\u6c17\u6301\u3061\u3060\u3068\u601d\u3044\u307e\u3059\u3002\u79c1\u305f\u3061\u533b\u5e2b\u306f\u3067\u304d\u308b\u9650\u308a\u305d\u306e\u60c5\u5831\u306e\u771f\u507d\u306b\u3064\u3044\u3066\u78ba\u8a8d\u3057\u3066\u3044\u304f\u8cac\u4efb\u304c\u3042\u308a\u307e\u3059\u3002\u8a3c\u62e0\u306b\u57fa\u3065\u3044\u305f\u533b\u7642(Evidenced Based Medicine:EBM) \u304c\u5927\u5207\u3060\u3001\u3068\u3002<\/p>\n
\u3000\u79c1\u304c\u533b\u5e2b\u306b\u306a\u3063\u305f\u5f53\u6642\u3001\u514d\u75ab\u7642\u6cd5\u306f\u5143\u3005\u306e\u514d\u75ab\u3092\u8ce6\u6d3b\u5316\u3057\u3066\u7528\u3044\u308b\u304b\u3089\u526f\u4f5c\u7528\u306e\u5c11\u306a\u3044\u6cbb\u7642\u3060\u3088\u3001\u3067\u304d\u305f\u3089\u7d20\u6674\u3089\u3057\u3044\u306d\u3001\u3068\u8a00\u308f\u308c\u305f\u3082\u306e\u3067\u3057\u305f\u3002\u3057\u304b\u3057\u3001\u9577\u3044\u9593\u3001\u514d\u75ab\u7642\u6cd5\u306f\u306a\u304b\u306a\u304b\u3046\u307e\u304f\u958b\u767a\u3055\u308c\u307e\u305b\u3093\u3067\u3057\u305f\u304c\u3001\u3053\u306e\u514d\u75ab\u30c1\u30a7\u30c3\u30af\u30dd\u30a4\u30f3\u30c8\u963b\u5bb3\u85ac\u306f\u514d\u75ab\u7642\u6cd5\u306e\u30d6\u30ec\u30a4\u30af\u30b9\u30eb\u30fc\u3068\u3057\u3066\u671f\u5f85\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u78ba\u304b\u306b\u3001\u81e8\u5e8a\u8a66\u9a13\u306e\u7d50\u679c\u3092\u898b\u308b\u3068\u5f93\u6765\u306e\u6a19\u6e96\u6cbb\u7642\u3068\u6bd4\u3079\u3066\u826f\u3044\u7d50\u679c\u304c\u51fa\u3066\u3044\u308b\u3082\u306e\u3082\u3042\u308a\u307e\u3059\u3002\u591a\u304f\u306e\u4eba\u305f\u3061\u304c\u304d\u3061\u3093\u3068\u7814\u7a76\u3057\u3001\u81e8\u5e8a\u8a66\u9a13\u3092\u884c\u3063\u3066\u3001\u85ac\u3068\u3057\u3066\u4f7f\u3046\u3053\u3068\u304c\u3067\u304d\u308b\u3088\u3046\u306b\u306a\u308a\u307e\u3057\u305f\u3002\u526f\u4f5c\u7528\u3082\u3082\u3061\u308d\u3093\u3042\u308a\u307e\u3059\u3002\u305d\u308c\u3082\u601d\u3044\u304c\u3051\u306a\u3044\u3082\u306e\u3082\u3002\u6c7a\u3057\u3066\u300c\u5922\u306e\u85ac\u300d\u306a\u3069\u3067\u306f\u306a\u304f\u3001\u533b\u5e2b\u3068\u60a3\u8005\u3055\u3093\u304c\u305d\u306e\u30e1\u30ea\u30c3\u30c8\u3001\u30c7\u30e1\u30ea\u30c3\u30c8\u3092\u8a71\u3057\u5408\u3063\u3066\u4f7f\u3063\u3066\u3044\u304f\u3068\u3044\u3046\u5f93\u6765\u306e\u304a\u85ac\u3068\u5168\u304f\u540c\u3058\u3067\u3042\u308d\u3046\u3068\u8003\u3048\u3066\u3044\u307e\u3059\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"
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